Cutaneous Adverse Reactions Associated with COVID-19 Vaccines
SARS-CoV-2 vaccination is crucial to reduce the risk of hospitalization, injury
and mortality. However, several adverse cutaneous reactions can occur.
Objective was to collect and classify cutaneous side effects after SARS-CoV-2
vaccination in a Moroccan case series.
1.3. Methods: A
cross-sectional observational study among patients referred to the Dermatology
Department of Ibn Rochd Hospital from February 2021 to November 2021. Patients
of all ages vaccinated against COVID-19 who developed a skin manifestation
within 1 month of administration of vaccine that had been approved by the
national technical and scientific committee in Morocco (Sinopharm and
Astrazeneca then Pfizer-BioNTech). Patients with explainable causes other than
SARS-CoV-2 vaccination were excluded.
1.4. Results: A
total of 47 patients were identified with cutaneous reactions after COVID-19
vaccination: AstraZeneca (53,19 %), Sinopharm (38,29 %), and
mRNAPfizer-BioNTech vaccine (8,51 %). Allergic-type reactions (46.80%):
urticaria (10.63%), urticaria with angioedema (10.63%), pruritus (10.63%),
morbilliform eruption (4.25%), Quincke's edema (2.12%), DRESS (Drug Reaction with
Eosinophilia and Systemic Symptoms) syndrome (2.12%), Stevens-Johnson syndrome
(2.12%), lichenoid drug eruption (2.12%), anaphylactic reaction (2.12%).
Inflammatory skin reactions (17.02%): Erythema nodosum (8.51%), psoriasis
(4.25%), lupus (2.12%), Shulman fasciitis (2.12%). Autoimmune reactions
(14.89%): bullous pemphigoid (6.38%), pemphigus vulgaris (2,12%), urticarial
vasculitis (4.25%) and vitiligo (2.12%). Viral reactivation: zoster
reactivations (8.51%), herpetic reactivations (4.25%). Reactions described
after infection with COVID-19: erythema multiforme (4.25%), Varicella-like rash
(2.12%). In addition, a generalized annular rash was noted in a single patient