Impact of Plasmodium Falciparum Malaria on Liver and Red Blood Cell
Malaria remains one of the greatest
public health challenges worldwide, particularly in tropical and sub-tropical
countries. Estimates about 212 million and 429.000 death per year worldwide.
The liver and red blood cell (RBC) are the organ that has clearly changed in
the early stages of infection. The aim of this study was to elucidate the
inflamed sinusoidal area showing the change of liver morphology in severe
Plasmodium falciparum (P. falciparum) malaria infection and red blood cell
anatomical changes. P. falciparum malaria invasion associated with endothelial
activation and expression of adhesion molecules. Some infected RBCs can be
eliminated by the host immune system. However, some carry on infection which
leading to severe malaria. Decrease deformability of erythrocyte infected by
malaria parasites may play a role of enrichment in the liver. The different
sizes and shapes of infected RBC in the liver were resulted diversity
morphological of RBCs and their function in the infected organs.