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World Journal of Nutrition And Metabolism, Dietetics

Safety of Zolindronic Acid in Osteoporosis: A Descriptive Cross Sectional Study

1. Abstract

All bisphosphonates including zolindronic acid improve BMD in osteoporosis and decrease risk of spine, hip and other non-vertebral fractures significantly. The purpose of this study was to assess safety of zolindronic acid in osteoporosis in Kashmiri population. This was a descriptive cross sectional study conducted in tertiary care hospital of Kashmir valley. 77 pts were enrolled in the study with documented osteoporosis who received 5 mg zolindronic acid infusion with adequate prior hydration. All pts was followed for immediate adverse effects following infusion. Mild symptoms did occur in the form of fever, arthralgias, myalgias, muscle cramps and nausea. Majority of the symptoms subsided within two to three days of infusion. Our observations conclude that zolindronic acid is very much safe and fairly tolerated drug in osteoporosis.

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